a description of the patient case from your experiences, observations, and/or clinical practice from the last 5 years. Then, describe factors that might have influenced pharmacokinetic and pharmacodynamic processes of the patient you identified. Finally, explain details of the personalized plan of care that you would develop based on influencing factors and patient history in your case. Be specific and provide examples.

a description of the patient case from your experiences, observations, and/or clinical practice from the last 5 years. Then, describe factors that might have influenced pharmacokinetic and pharmacodynamic processes of the patient you identified. Finally, explain details of the personalized plan of care that you would develop based on influencing factors and patient history in your case. Be specific and provide examples.

There is currently a 14-year-old Type I DM in the school building that I work in. There are times when he comes to school with numbers well above 400+. My fear for this child is that he will be one of those individuals who end up with kidney failure. The explanation provided your paper on how drugs are metabolized in the diabetic body touched on the importance of adequate patient education, compliance, and follow-ups. It is essential to have a level of understanding of how the body functions when a patient has kidney failure. Understanding the pharmacodynamic and pharmacokinetics in the correlation to the pathophysiology of treating those with renal failure is essential when creating a management or treatment plan. 

Reading your paper, the relationship between the two mechanisms of actions works together as a cause and effect. In the article, Principles of Drug Response and Alterations in Kidney Disease, the level of a drug’s concentration works in conjunction with its effects in the body (Keller & Hann, 2018). It precisely explains the kinetics and dynamics of a drug’s movement through the body system. It is this cause and effect approach that allows a drug to work in the body to produce an action. In regards to the effects of a drug’s movement in patients with kidney failure, Keller and Hann’s article also inferred that pharmacokinetics is usually considered over pharmacodynamics when prescribing medications for the treatment of those with kidney disease (2018). However, pharmacodynamics is rarely considered drug metabolism in those with kidney disease. Nevertheless, when both mechanisms are reported, drug dosing can be modified per patient for better efficacy.  

Reference:

Keller, F., & Hann, A. (2020). Clinical Pharmacodynamics Principles of Drug Response and  Alterations in Kidney Disease.

Clinical Journal of the American Society of Nephrology, 15(8), 1073–1074. https://doi.org/doi.org/10.1016/j.pedn.2017.05.001 0882-5963/