Appropriate dosing, administration route, and any considerations for dosing alterations

Appropriate dosing, administration route, and any considerations for dosing alterations

Chlorpromazinecan be administered orally or through intravenous and intramuscular injections. The dosing depends on the patient (Mann & Marwaha, 2023). Orally, schizophrenic patients can start on 25-75 mg/day orally twice a day before maintenance at 200 mg/day. Maximum dose is at 800 mg/day. If through intravenous or intramuscular route, the dose can begin at 25 mg, then 25-50 mg after 1-4 hours. Unusual dose is at 300-800 mg day. For nausea and vomiting, the oral dose is 10-25 mg orally every 4-6 hrs as needed. The dose for intravenous/intramuscular injection can be 25-50 mg every 4-6 hrs as needed. For persistent singultus, the oral dose is 25-50 mg every 6-8 hrs. It can be given through the intramuscular/intravenous route if the symptoms persist for 2-3 days after the oral dose. For preoperative apprehension, the dose is 25-50 mg orally and 12.5-25 mg intramuscularly 2-3 hours before surgery. No renal dose adjustments or supplement for dialysis patients required. However, caution is advised for those with hepatic impairment. Considerations of use and dosing in specific specialty populations In children, the oral dose is initially 0.55 mg/kg every 4-6 hours as required. The dose can be increased gradually every 3-4 days to control symptoms. High doses may be required for severe psychotic conditions (50-100 mg/day for younger or 200 mg/day for older children).