NURS 6501 Module 5 Assignment: Case Study Analysis Advanced pathophysiology

NURS 6501 Module 5 Assignment: Case Study Analysis Advanced pathophysiology

Hyperuricemia is a health condition known to be commonly caused by a decrease in renal excretion. Patients utilizing diuretics such as hydrochlorothiazide are at a higher risk of developing the disease. However, the disease might also be genetically passed from parents to children. An increase in the turnover of nucleoprotein in the hematologic condition may result to an increase in urate production (Singh & Gaffo, 2020). Nucleoprotein turnover occurring in conditions of high rate of cell death and cellular proliferation may also impact high production of urate. Obesity which is an abnormal body weight may also cause an increased urate production which correlates with surface area to volume ratio of body size.

Neurological processes

         An acute gout flare is characterized by pain as the primary symptom. Several factors may account for the felt pain. Bradykinin and prostaglandins production may be one factor that might impact the pain. Nociceptors’s sensitization may also account for this pain. Stimulation of unmyelinated nerve fibres results to neuropeptides release (Mei et al., 2019). For instance substance P which is an example of neuropeptides might be released. A release of substance P results to production of cytokines and PGs. It is also characterized by processes such as leukocytes recruitment, vasodilation, mast cell degranulation and plasma extravasation.

Musculoskeletal process

         Continuous and multiple flare-ups makes gout to become persistent and severe. Due to this reason deformity of a joint is developed. As time goes by, one progressively develops difficulties in joint motions. The uric acid crystals accounts for the damage in these joints and tendons. Developing gout is characterized by urate precipitation that results in monosodium-urate crystals that are needle-shaped. These crystals are found as deposits in vascular tissues such as cartilage and in other avascular tissues such as walls of bursae, tendons, ligaments and tendon sheaths (Zhang et al., 2018). The crystals may also be deposited within the skin closer to tissues and cooler distal joints such as those of the ears.