Question 4: Pathology of Type 2 DM

Question 4: Pathology of Type 2 DM

Type 2 DM, in contrast to type 1 DM, results from absolute insulin deficiency, results from relative insulin deficiency due to reduced secretion of insulin by the pancreas, increased insulin resistance by the peripheral tissues, or both (Galicia-Garcia et al., 2020). It can also be due to increased levels of insulin counterregulatory hormones. This relative insulin deficiency leads to reduced utilization of glucose in the affected individual, and the lipids are metabolized instead (Banday et al., 2020). This is the hallmark of hyperglycemia and other patient presentation encountered in type 2 DM.