RE: Week 1 Discussion Alteration in cellular Processes

RE: Week 1 Discussion Alteration in cellular Processes

I enjoyed reading your discussion post this week and found it to be very informative. GAS infections, precursors of both invasive and immune-mediated disease sequelae, are present with 111 million prevalent cases of GAS in children and more than 600 million new cases of GAS pharyngitis per year ( Dasom & Soo, 2021). Sustained control of GAS infections in settings of poverty has proven to be challenging, and an effective vaccine may be the most practical long-term strategy to reduce the burden of GAS-related diseases such as rheumatic heart disease and post-streptococcal glomerulonephritis. Appropriate use of laboratory testing for GAS pharyngitis and prescription of antibiotics is imperative. Antibiotics cause adverse drug reactions and immune-mediated hypersensitivity reactions such as anaphylaxis (Blumenthal et al., 2018). Blumenthal et al. (2018) further note that while 5%-15% of patients in developed countries carry an allergy from the β-Lactam drugs class, it is rare for a medication such as Amoxicillin to cause an IgE-mediated anaphylactic response ( Campbell et al., 2018). The explanation you provided describing the release of mast cells, basophils, and histamine makes logical sense as to why the patient experienced angioedema, difficulty breathing, and wheezing.

References

Campbell, P. T., Frost, H., Smeesters, P. R., Kado, J., Good, M. F., Batzloff, M., Geard, N., McVernon, J., & Steer, A. (2018). Investigation of group A Streptococcus immune responses in an endemic setting, with a particular focus on J8. Vaccine, 36(50), 7618–7624. https://doi-org.ezp.waldenulibrary.org/10.1016/j.vaccine.2018.10.091