The Process of Immunosuppression and the Effect it has on Body Systems

 

Immunosuppression refers to the process of weakening the activity of the immune system. Induced immunosuppression is the process of deliberately reducing the activity of the immune system by administration of drugs such as azathioprine, corticosteroids, and cyclosporine to patients mainly following graft transplant to reduce graft rejection by the host. In some disease processes like Glioma, Glioma cells start the immunosuppressive network that impairs the activity of the effector cell and decreases the efficiency of any therapeutic measures to restore normal immunity (Mangani et al., 2017). Immunosuppression can also occur following an adverse reaction in disease treatment. The whole process reduces the efficiency of the immune system in fighting diseases, making the patient more susceptible to infections.

     References

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Jenks, J. D., & Hoenigl, M. (2020). Point-of-care diagnostics for invasive aspergillosis: Nearing the finish line. Expert Review of Molecular Diagnostics20(10), 1009-1017. https://doi.org/10.1111/myc.12881

Lupiañez, C. B., Villaescusa, M. T., Carvalho, A., Springer, J., Lackner, M., Sánchez-Maldonado, J. M., … & PCRAGA Study Group. (2016). Common genetic polymorphisms within NFκB-related genes and the risk of developing invasive aspergillosis. Frontiers in microbiology7, 1243. https://doi.org/10.3389/fmicb.2016.01243

Mangani, D., Weller, M., & Roth, P. (2017). The network of immunosuppressive pathways in glioblastoma. Biochemical pharmacology130, 1-9. https://doi.org/10.1016/j.bcp.2016.12.011

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