According to Konoplia et al, 2022, the development of hyperactive states is associated with an
increase in the quantitative and functional characteristics of the effector components of immunity
and/or a lack of suppressive factors. The parameters to reduce would be, blood glucose levels at
143dL/ML on day 3 should be lowered further. High levels of white blood cells of over 10,000, as
evidenced by positive lab results of the continued presence of bacterial infection should be
responding at a faster rate to an antibacterial by day 3 of treatment. I would continue the
antibacterial treatment of Ceftriaxone 1 gm IV daily to continue the treatment of bacterial
infection, even though it was started as an empiric treatment. These features or their combinations
underlie the development of the infectious pathology of pneumonia. Ceftriaxone is in the class of
cephalosporin, and beta-lactam, which work by binding to penicillin-binding proteins. It is a
broad-spectrum bactericidal which disrupts cell wall synthesis, and activates autolysins, killing the
bacteria, (Rosenthal & Burchum, 2021).
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